Policy- and payment-driven imperatives will drive operations across hospitals, medical groups, and health systems in the next several years, as the overall cost of the U.S. healthcare system moves towards system unsustainability. Among the key trends will be the shift, wherever possible, of care delivery from the most acute care delivery sites to less acute sites of care, particularly towards and into care into the home, including through hospital-at-home programs; and the shift into intensive population health and care management for the vast majority of patients living with chronic illnesses. In the context of such imperatives, what new and emerging technologies will come to the forefront? A panel of health system leaders will look at the possibilities, and the opportunities.