After Dr. Zachariah earned his medical degree from Chicago Medical School, he completed a Family Medicine/Tropical Medicine residency in Whittier at Presbyterian Intercommunity Hospital, followed by a fellowship in Hospice and Palliative Medicine at Kaiser in Los Angeles and has earned the degree of fellow for his work in Family Medicine, Hospice & Palliative Medicine, and Clinical Informatics. Combining his training in tropical medicine with his humanitarian values, Dr. Zachariah has volunteered significant time in underserved parts of the world teaching palliative care and helping patients in Cameroon, Zambia, India and Ethiopia.

He is currently the City of Hope physician lead for the improving goal concordant care initiative and also serves as an associate chief medical information officer, with a focus on quality and regulatory programs as well as supporting his colleagues in the adoption of clinical technologies and refining the electronic health record system to improve care delivery. His programmatic and academic focus includes tailoring patient care to individual values and goals, advance care planning, and leveraging technology to enhance the coordination and delivery of patient-centered medical care in serious illness.